Synthesis of a polymerizable, bivalent glycan mimetic of the HIV envelope spike gp120.
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ABSTRACT:
SUBMITTER: Sletten ET
PROVIDER: S-EPMC4442089 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
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Synthesis of a polymerizable, bivalent glycan mimetic of the HIV envelope spike gp120.
Sletten Eric T ET Svec Riley L RL Nguyen Hien M HM
Tetrahedron letters 20150601 23
A synthetic study on the creation of a bivalent, ROMP capable monomer has the ability to be polymerized into the corresponding neo-glycopolymer mimetic of the surface glycans on gp120 envelope spike of the HIV virus. In our approach, we have developed a new strategy for orthogonally attaching both the terminal Manα1-2Man disaccharide unit of the D1 arm of Man9GlcNAc2 of HIV gp120 and the terminal Manα1-2 unit of its D2 arm to a bivalent scaffold to produce the corresponding polymerizable monomer ...[more]
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