Structure of Serotype 1 Reovirus Attachment Protein ?1 in Complex with Junctional Adhesion Molecule A Reveals a Conserved Serotype-Independent Binding Epitope.
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ABSTRACT:
SUBMITTER: Stettner E
PROVIDER: S-EPMC4442426 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
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Structure of Serotype 1 Reovirus Attachment Protein σ1 in Complex with Junctional Adhesion Molecule A Reveals a Conserved Serotype-Independent Binding Epitope.
Stettner Eva E Dietrich Melanie H MH Reiss Kerstin K Dermody Terence S TS Stehle Thilo T
Journal of virology 20150325 11
Mammalian orthoreoviruses use glycans and junctional adhesion molecule A (JAM-A) as attachment receptors. We determined the structure of serotype 1 reovirus attachment protein σ1 alone and in complex with JAM-A. Comparison with the structure of serotype 3 reovirus σ1 bound to JAM-A reveals that both σ1 proteins engage JAM-A with similar affinities and via conserved binding epitopes. Thus, σ1-JAM-A interactions are unlikely to explain the differences in pathogenesis displayed by these reovirus se ...[more]
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