Association of CRR9 locus with elevated risk of squamous cell carcinoma and basal cell carcinoma.

ABSTRACT: BACKGROUND:Published studies have generated inconsistent results related to the contribution of CRR9 rs401681 C allele to the risk of developing non-melanoma skin cancer (NMSC), and it is the inconsistency that promoted us to undertake a meta-analysis to identify the degree of impact the C allele has on NMSC. METHOD:The PubMed, Science Direct, Embase and Cochrane Library were thoroughly searched from the start of November 2013 to the end of April 2014 by using CRR9, polymorphism, skin cancer and their synonyms. Based on a total of 44,036 subjects, we calculated ORs and 95% CIs to measure the influence of the C allele on NMSC predisposition. RESULTS:Overall, individuals carrying the risk C allele at rs401681 had 1.16 times (OR = 1.16, 95% CI: 1.10-1.21, heterogeneity: P = 0.298 and I2 = 0.166, Figure 2) greater risk of NMSC compared to the common T allele. In the further stratified analyses, we found a significant association between the C allele and BCC, Icelanders, and non-Icelanders. CONCLUSION:The results of this meta-analysis suggest that the C allele at rs401681 is likely to modify the genetic predisposition to NMSC.

SUBMITTER: Liu T 

PROVIDER: S-EPMC4443106 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature