Ontology highlight
ABSTRACT:
SUBMITTER: Cybulski LE
PROVIDER: S-EPMC4443340 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Cybulski Larisa Estefanía LE Ballering Joost J Moussatova Anastassiia A Inda Maria Eugenia ME Vazquez Daniela B DB Wassenaar Tsjerk A TA de Mendoza Diego D Tieleman D Peter DP Killian J Antoinette JA
Proceedings of the National Academy of Sciences of the United States of America 20150504 20
DesK is a bacterial thermosensor protein involved in maintaining membrane fluidity in response to changes in environmental temperature. Most likely, the protein is activated by changes in membrane thickness, but the molecular mechanism of sensing and signaling is still poorly understood. Here we aimed to elucidate the mode of action of DesK by studying the so-called "minimal sensor DesK" (MS-DesK), in which sensing and signaling are captured in a single transmembrane segment. This simplified ver ...[more]