Connectivity reveals relationship of brain areas for reward-guided learning and decision making in human and monkey frontal cortex.

ABSTRACT: Reward-guided decision-making depends on a network of brain regions. Among these are the orbitofrontal and the anterior cingulate cortex. However, it is difficult to ascertain if these areas constitute anatomical and functional unities, and how these areas correspond between monkeys and humans. To address these questions we looked at connectivity profiles of these areas using resting-state functional MRI in 38 humans and 25 macaque monkeys. We sought brain regions in the macaque that resembled 10 human areas identified with decision making and brain regions in the human that resembled six macaque areas identified with decision making. We also used diffusion-weighted MRI to delineate key human orbital and medial frontal brain regions. We identified 21 different regions, many of which could

SUBMITTER: Neubert FX 

PROVIDER: S-EPMC4443352 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature