Ontology highlight
ABSTRACT:
SUBMITTER: Milenkovic A
PROVIDER: S-EPMC4443363 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Milenkovic Andrea A Brandl Caroline C Milenkovic Vladimir M VM Jendryke Thomas T Sirianant Lalida L Wanitchakool Potchanart P Zimmermann Stephanie S Reiff Charlotte M CM Horling Franziska F Schrewe Heinrich H Schreiber Rainer R Kunzelmann Karl K Wetzel Christian H CH Weber Bernhard H F BH
Proceedings of the National Academy of Sciences of the United States of America 20150504 20
In response to cell swelling, volume-regulated anion channels (VRACs) participate in a process known as regulatory volume decrease (RVD). Only recently, first insight into the molecular identity of mammalian VRACs was obtained by the discovery of the leucine-rich repeats containing 8A (LRRC8A) gene. Here, we show that bestrophin 1 (BEST1) but not LRRC8A is crucial for volume regulation in human retinal pigment epithelium (RPE) cells. Whole-cell patch-clamp recordings in RPE derived from human-in ...[more]