Ontology highlight
ABSTRACT:
SUBMITTER: Williams C
PROVIDER: S-EPMC4443378 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20150504 20
The initial phase of peroxisomal fission requires the peroxisomal membrane protein Peroxin 11 (Pex11p), which remodels the membrane, resulting in organelle elongation. Here, we identify an additional function for Pex11p, demonstrating that Pex11p also plays a crucial role in the final step of peroxisomal fission: dynamin-like protein (DLP)-mediated membrane scission. First, we demonstrate that yeast Pex11p is necessary for the function of the GTPase Dynamin-related 1 (Dnm1p) in vivo. In addition ...[more]