Dissecting the role of aberrant DNA methylation in human leukaemia.
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ABSTRACT:
SUBMITTER: Amabile G
PROVIDER: S-EPMC4443494 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
Dissecting the role of aberrant DNA methylation in human leukaemia.
Amabile Giovanni G Di Ruscio Annalisa A Müller Fabian F Welner Robert S RS Yang Henry H Ebralidze Alexander K AK Zhang Hong H Levantini Elena E Qi Lihua L Martinelli Giovanni G Brummelkamp Thijn T Le Beau Michelle M MM Figueroa Maria E ME Bock Christoph C Tenen Daniel G DG
Nature communications 20150522
Chronic myeloid leukaemia (CML) is a myeloproliferative disorder characterized by the genetic translocation t(9;22)(q34;q11.2) encoding for the BCR-ABL fusion oncogene. However, many molecular mechanisms of the disease progression still remain poorly understood. A growing body of evidence suggests that the epigenetic abnormalities are involved in tyrosine kinase resistance in CML, leading to leukaemic clone escape and disease propagation. Here we show that, by applying cellular reprogramming to ...[more]
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