Ontology highlight
ABSTRACT:
SUBMITTER: Kurian L
PROVIDER: S-EPMC4443804 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Kurian Leo L Aguirre Aitor A Sancho-Martinez Ignacio I Benner Christopher C Hishida Tomoaki T Nguyen Thai B TB Reddy Pradeep P Nivet Emmanuel E Krause Marie N MN Nelles David A DA Esteban Concepcion Rodriguez CR Campistol Josep M JM Yeo Gene W GW Belmonte Juan Carlos Izpisua JCI
Circulation 20150304 14
<h4>Background</h4>Long noncoding RNAs (lncRNAs) have emerged as critical epigenetic regulators with important functions in development and disease. Here, we sought to identify and functionally characterize novel lncRNAs critical for vertebrate development.<h4>Methods and results</h4>By relying on human pluripotent stem cell differentiation models, we investigated lncRNAs differentially regulated at key steps during human cardiovascular development with a special focus on vascular endothelial ce ...[more]