Ontology highlight
ABSTRACT:
SUBMITTER: Kang HM
PROVIDER: S-EPMC4444078 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Kang Hyun Mi HM Ahn Seon Ho SH Choi Peter P Ko Yi-An YA Han Seung Hyeok SH Chinga Frank F Park Ae Seo Deok AS Tao Jianling J Sharma Kumar K Pullman James J Bottinger Erwin P EP Goldberg Ira J IJ Susztak Katalin K
Nature medicine 20141201 1
Renal fibrosis is the histological manifestation of a progressive, usually irreversible process causing chronic and end-stage kidney disease. We performed genome-wide transcriptome studies of a large cohort (n = 95) of normal and fibrotic human kidney tubule samples followed by systems and network analyses and identified inflammation and metabolism as the top dysregulated pathways in the diseased kidneys. In particular, we found that humans and mouse models with tubulointerstitial fibrosis had l ...[more]