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ABSTRACT: Background
Resting heart rate (RHR) reflects sympathetic nerve activity a significant association between RHR and all-cause and cardiovascular mortality has been reported in some epidemiologic studies.Methods
To analyze the predictive power and accuracy of RHR as a screening measure for individual and clustered cardiovascular risk in adolescents. The study comprised 769 European adolescents (376 boys) participating in the HELENA cross-sectional study (2006-2008) were included in this study. Measurements on systolic blood pressure, HOMA index, triglycerides, TC/HDL-c, VO2máx and the sum of four skinfolds were obtained, and a clustered cardiovascular disease (CVD) risk index was computed. The receiver operating characteristics curve was applied to calculate the power and accuracy of RHR to predict individual and clustered CVD risk factors.Results
RHR showed low accuracy for screening CVD risk factors in both sexes (range 38.5%-54.4% in boys and 45.5%-54.3% in girls). Low specificity's (15.6%-19.7% in boys; 18.1%-20.0% in girls) were also found. Nevertheless, the sensitivities were moderate-to-high (61.4%-89.1% in boys; 72.9%-90.3% in girls).Conclusion
RHR is a poor predictor of individual CVD risk factors and of clustered CVD and the estimates based on RHR are not accurate. The use of RHR as an indicator of CVD risk in adolescents may produce a biased screening of cardiovascular health in both sexes.
SUBMITTER: de Moraes AC
PROVIDER: S-EPMC4444318 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
de Moraes Augusto César Ferreira AC Cassenote Alex Jones Flores AJ Leclercq Catherine C Dallongeville Jean J Androutsos Odysseas O Török Katalin K González-Gross Marcela M Widhalm Kurt K Kafatos Anthony A Carvalho Heráclito Barbosa HB Moreno Luis Alberto LA
PloS one 20150526 5
<h4>Background</h4>Resting heart rate (RHR) reflects sympathetic nerve activity a significant association between RHR and all-cause and cardiovascular mortality has been reported in some epidemiologic studies.<h4>Methods</h4>To analyze the predictive power and accuracy of RHR as a screening measure for individual and clustered cardiovascular risk in adolescents. The study comprised 769 European adolescents (376 boys) participating in the HELENA cross-sectional study (2006-2008) were included in ...[more]