Ontology highlight
ABSTRACT:
SUBMITTER: Brundage L
PROVIDER: S-EPMC4444781 | biostudies-literature | 1996 May
REPOSITORIES: biostudies-literature
Neuron 19960501 5
We find that C. elegans egl-30 encodes a heterotrimeric G protein a subunit more than 80% identical to mammalian Gqalpha family proteins, and which can function as a Gqalpha subunit in COS-7 cells. We have identified new egl-30 alleles in a selection for genes involved in the C. elegans acetylcholine response. Two egl-30 alleles specify premature termination of Gqalpha and are essentially lethal in homozygotes. Animals homozygous for six other egl-30 alleles are viable and fertile, but exhibit d ...[more]