Ontology highlight
ABSTRACT:
SUBMITTER: Richter M
PROVIDER: S-EPMC4445001 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Richter Maximilian M Yumul Roma R Wang Hongjie H Saydaminova Kamola K Ho Martin M May Drew D Baldessari Audrey A Gough Michael M Drescher Charles C Urban Nicole N Roffler Steve S Zubieta Chloé C Carter Darrick D Fender Pascal P Lieber André A
Molecular therapy. Methods & clinical development 20150311
A central treatment resistance mechanism in solid tumors is the maintenance of epithelial junctions between malignant cells that prevent drug penetration into the tumor. We have developed a small recombinant protein (JO-1) that triggers the transient opening of intercellular junctions and thus increases the efficacy of monoclonal antibodies and chemotherapeutic drugs without causing toxicity in mouse tumor models. Here, we provide data toward the clinical translation of an affinity-enhanced vers ...[more]