Ontology highlight
ABSTRACT:
SUBMITTER: Lourenco CF
PROVIDER: S-EPMC4445047 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Lourenço Cátia F CF Ledo Ana A Dias Cândida C Barbosa Rui M RM Laranjinha João J
Frontiers in aging neuroscience 20150527
The functional and structural integrity of the brain requires local adjustment of blood flow and regulated delivery of metabolic substrates to meet the metabolic demands imposed by neuronal activation. This process-neurovascular coupling-and ensued alterations of glucose and oxygen metabolism-neurometabolic coupling-are accomplished by concerted communication between neural and vascular cells. Evidence suggests that neuronal-derived nitric oxide ((•)NO) is a key player in both phenomena. Alterat ...[more]