Ontology highlight
ABSTRACT:
SUBMITTER: Cordero-Llana O
PROVIDER: S-EPMC4445614 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Cordero-Llana Óscar Ó Houghton Benjamin C BC Rinaldi Federica F Taylor Hannah H Yáñez-Muñoz Rafael J RJ Uney James B JB Wong Liang-Fong LF Caldwell Maeve A MA
Molecular therapy : the journal of the American Society of Gene Therapy 20141105 2
Cerebral Dopamine Neurotrophic Factor (CDNF) and Mesencephalic Astrocyte-derived Neurotrophic factor (MANF) are members of a recently discovered family of neurotrophic factors (NTFs). Here, we used intranigral or intrastriatal lentiviral vector-mediated expression to evaluate their efficacy at protecting dopaminergic function in the 6-OHDA model of Parkinson's disease (PD). In contrast to the well-studied Glial-Derived Neurotrophic Factor (GDNF), no beneficial effects were demonstrated by striat ...[more]