Ontology highlight
ABSTRACT:
SUBMITTER: Schonfeld K
PROVIDER: S-EPMC4445620 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Schönfeld Kurt K Sahm Christiane C Zhang Congcong C Naundorf Sonja S Brendel Christian C Odendahl Marcus M Nowakowska Paulina P Bönig Halvard H Köhl Ulrike U Kloess Stephan S Köhler Sylvia S Holtgreve-Grez Heidi H Jauch Anna A Schmidt Manfred M Schubert Ralf R Kühlcke Klaus K Seifried Erhard E Klingemann Hans G HG Rieger Michael A MA Tonn Torsten T Grez Manuel M Wels Winfried S WS
Molecular therapy : the journal of the American Society of Gene Therapy 20141106 2
Natural killer (NK) cells are an important effector cell type for adoptive cancer immunotherapy. Similar to T cells, NK cells can be modified to express chimeric antigen receptors (CARs) to enhance antitumor activity, but experience with CAR-engineered NK cells and their clinical development is still limited. Here, we redirected continuously expanding and clinically usable established human NK-92 cells to the tumor-associated ErbB2 (HER2) antigen. Following GMP-compliant procedures, we generated ...[more]