Ontology highlight
ABSTRACT:
SUBMITTER: Cao R
PROVIDER: S-EPMC4446158 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Cao Ruifeng R Gkogkas Christos G CG de Zavalia Nuria N Blum Ian D ID Yanagiya Akiko A Tsukumo Yoshinori Y Xu Haiyan H Lee Choogon C Storch Kai-Florian KF Liu Andrew C AC Amir Shimon S Sonenberg Nahum N
Nature neuroscience 20150427 6
The circadian (∼24 h) clock is continuously entrained (reset) by ambient light so that endogenous rhythms are synchronized with daily changes in the environment. Light-induced gene expression is thought to be the molecular mechanism underlying clock entrainment. mRNA translation is a key step of gene expression, but the manner in which clock entrainment is controlled at the level of mRNA translation is not well understood. We found that a light- and circadian clock-regulated MAPK/MNK pathway led ...[more]