Ontology highlight
ABSTRACT:
SUBMITTER: Shen S
PROVIDER: S-EPMC4446421 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Shen Shensi S Rodrigo Guillermo G Prakash Satya S Majer Eszter E Landrain Thomas E TE Kirov Boris B Daròs José-Antonio JA Jaramillo Alfonso A
Nucleic acids research 20150427 10
Organisms have different circuitries that allow converting signal molecule levels to changes in gene expression. An important challenge in synthetic biology involves the de novo design of RNA modules enabling dynamic signal processing in live cells. This requires a scalable methodology for sensing, transmission, and actuation, which could be assembled into larger signaling networks. Here, we present a biochemical strategy to design RNA-mediated signal transduction cascades able to sense small mo ...[more]