Ontology highlight
ABSTRACT:
SUBMITTER: Kim SA
PROVIDER: S-EPMC4446439 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Kim Sang-Ah SA Chatterjee Nilanjana N Jennings Matthew J MJ Bartholomew Blaine B Tan Song S
Nucleic acids research 20150427 10
The promoter regions of active genes in the eukaryotic genome typically contain nucleosomes post-translationally modified with a trimethyl mark on histone H3 lysine 4 (H3K4), while transcriptional enhancers are marked with monomethylated H3K4. The flavin-dependent monoamine oxidase LSD1 (lysine-specific demethylase 1, also known as KDM1) demethylates mono- and dimethylated H3K4 in peptide substrates, but requires the corepressor protein, CoREST, to demethylate nucleosome substrates. The molecula ...[more]