Ontology highlight
ABSTRACT:
SUBMITTER: Smithers B
PROVIDER: S-EPMC4446445 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Nucleic acids research 20150430 10
We have discovered that positions of splice junctions in genes are constrained by the tolerance for disorder-promoting amino acids in the translated protein region. It is known that efficient splicing requires nucleotide bias at the splice junction; the preferred usage produces a distribution of amino acids that is disorder-promoting. We observe that efficiency of splicing, as seen in the amino-acid distribution, is not compromised to accommodate globular structure. Thus we infer that it is the ...[more]