Ontology highlight
ABSTRACT:
SUBMITTER: Dickson MA
PROVIDER: S-EPMC4446476 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Dickson Mark A MA D'Adamo David R DR Keohan Mary L ML D'Angelo Sandra P SP Carvajal Richard D RD Gounder Mrinal M MM Maki Robert G RG Qin Li-Xuan LX Lefkowitz Robert A RA McKennon Olivia R OR Hirst Catherine M CM Schwartz Gary K GK Tap William D WD
Sarcoma 20150514
Gemcitabine (G) and docetaxel (D) are commonly used to treat recurrent/metastatic soft tissue sarcoma. This study tested the hypothesis that outcomes would be improved by addition of bevacizumab (B). The initial design was randomized double-blind trial of G + D + B versus G + D + placebo. Due to slow accrual this was modified to single-arm open-label G + D + B. Eligible patients had diagnosis of leiomyosarcoma, pleomorphic undifferentiated sarcoma, pleomorphic liposarcoma, or angiosarcoma. Treat ...[more]