Ontology highlight
ABSTRACT:
SUBMITTER: Mohrin M
PROVIDER: S-EPMC4447312 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Mohrin Mary M Shin Jiyung J Liu Yufei Y Brown Katharine K Luo Hanzhi H Xi Yannan Y Haynes Cole M CM Chen Danica D
Science (New York, N.Y.) 20150301 6228
Deterioration of adult stem cells accounts for much of aging-associated compromised tissue maintenance. How stem cells maintain metabolic homeostasis remains elusive. Here, we identified a regulatory branch of the mitochondrial unfolded protein response (UPR(mt)), which is mediated by the interplay of SIRT7 and NRF1 and is coupled to cellular energy metabolism and proliferation. SIRT7 inactivation caused reduced quiescence, increased mitochondrial protein folding stress (PFS(mt)), and compromise ...[more]