Ontology highlight
ABSTRACT:
SUBMITTER: Taniguchi K
PROVIDER: S-EPMC4447318 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Nature 20150225 7541
Inflammation promotes regeneration of injured tissues through poorly understood mechanisms, some of which involve interleukin (IL)-6 family members, the expression of which is elevated in many diseases including inflammatory bowel diseases and colorectal cancer. Here we show in mice and human cells that gp130, a co-receptor for IL-6 cytokines, triggers activation of YAP and Notch, transcriptional regulators that control tissue growth and regeneration, independently of the gp130 effector STAT3. T ...[more]