Ontology highlight
ABSTRACT:
SUBMITTER: Welner RS
PROVIDER: S-EPMC4447336 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Welner Robert S RS Amabile Giovanni G Bararia Deepak D Czibere Akos A Yang Henry H Zhang Hong H Pontes Lorena Lobo De Figueiredo LL Ye Min M Levantini Elena E Di Ruscio Annalisa A Martinelli Giovanni G Tenen Daniel G DG
Cancer cell 20150501 5
Leukemic cells disrupt normal patterns of blood cell formation, but little is understood about the mechanism. We investigated whether leukemic cells alter functions of normal hematopoietic stem and progenitor cells. Exposure to chronic myelogenous leukemia (CML) caused normal mouse hematopoietic progenitor cells to divide more readily, altered their differentiation, and reduced their reconstitution and self-renewal potential. Interestingly, the normal bystander cells acquired gene expression pat ...[more]