Ontology highlight
ABSTRACT:
SUBMITTER: Silvennoinen O
PROVIDER: S-EPMC4447858 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Silvennoinen Olli O Hubbard Stevan R SR
Blood 20150330 22
The critical role of Janus kinase-2 (JAK2) in regulation of myelopoiesis was established 2 decades ago, but identification of mutations in the pseudokinase domain of JAK2 in myeloproliferative neoplasms (MPNs) and in other hematologic malignancies highlighted the role of JAK2 in human disease. These findings have revolutionized the diagnostics of MPNs and led to development of novel JAK2 therapeutics. However, the molecular mechanisms by which mutations in the pseudokinase domain lead to hyperac ...[more]