Physiologic and molecular changes in the tracheal epithelium of rats following burn injury.
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ABSTRACT:
SUBMITTER: Jacob S
PROVIDER: S-EPMC4448086 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
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Physiologic and molecular changes in the tracheal epithelium of rats following burn injury.
Jacob Sam S Zhu Yong Y Kraft Robert R Cotto Christopher C Carmical Joseph R JR Wood Thomas G TG Enkhbaatar Perenlei P Herndon David N DN Hawkins Hal K HK Cox Robert A RA
International journal of burns and trauma 20150320 1
Pneumonia is the leading complication in the critical care of burn victims. Airway epithelial dysfunction compromises host defense against pneumonia. The aim of this study is to test the hypothesis that burn injury alters the physiology of the airway epithelium. A rat model of 60% TBSA third degree scald burn was used. At 24 hours after injury, tracheal epithelial ultrastructure was studied using transmission electron microscopy (TEM) and proliferation was measured by Ki67 immunohistochemistry. ...[more]
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