Ontology highlight
ABSTRACT:
SUBMITTER: Sreesankar E
PROVIDER: S-EPMC4448129 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Sreesankar Easwaran E Bharathi Vellaichamy V Mishra Rakesh K RK Mishra Krishnaveni K
Scientific reports 20150529
Rif1, identified as a regulator of telomerase in yeast, is an evolutionarily conserved protein and functions in diverse processes including telomere length regulation, epigenetic gene regulation, anti-checkpoint activity, DNA repair and establishing timing of firing at replication origins. Previously we had identified that all Rif1 homologues have PP1 interacting SILK-RVxF motif. In the present study, we show that Drosophila Rif1 is essential for normal fly development and loss of dRif1 impairs ...[more]