Recurrence-associated pathways in hepatitis B virus-positive hepatocellular carcinoma.

ABSTRACT:

Background

Despite the recent identification of several prognostic gene signatures, the lack of common genes among experimental cohorts has posed a considerable challenge in uncovering the molecular basis underlying hepatocellular carcinoma (HCC) recurrence for application in clinical purposes. To overcome the limitations of individual gene-based analysis, we applied a pathway-based approach for analysis of HCC recurrence.

Results

By implementing a permutation-based semi-supervised principal component analysis algorithm using the optimal principal component, we selected sixty-four pathways associated with hepatitis B virus (HBV)-positive HCC recurrence (p < 0.01), from our microarray dataset composed of 142 HBV-positive HCCs. In relation to the public HBV- and public hepatit

SUBMITTER: Kim BY 

PROVIDER: S-EPMC4448317 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature