Ontology highlight
ABSTRACT:
SUBMITTER: Hose J
PROVIDER: S-EPMC4448642 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Hose James J Yong Chris Mun CM Sardi Maria M Wang Zhishi Z Newton Michael A MA Gasch Audrey P AP
eLife 20150508
Aneuploidy is linked to myriad diseases but also facilitates organismal evolution. It remains unclear how cells overcome the deleterious effects of aneuploidy until new phenotypes evolve. Although laboratory strains are extremely sensitive to aneuploidy, we show here that aneuploidy is common in wild yeast isolates, which show lower-than-expected expression at many amplified genes. We generated diploid strain panels in which cells carried two, three, or four copies of the affected chromosomes, t ...[more]