Dataset Information

Development of biodegradable Zn-1X binary alloys with nutrient alloying elements Mg, Ca and Sr.

ABSTRACT: Biodegradable metals have attracted considerable attentions in recent years. Besides the early launched biodegradable Mg and Fe metals, Zn, an essential element with osteogenic potential of human body, is regarded and studied as a new kind of potential biodegradable metal quite recently. Unfortunately, pure Zn is soft, brittle and has low mechanical strength in the practice, which needs further improvement in order to meet the clinical requirements. On the other hand, the widely used industrial Zn-based alloys usually contain biotoxic elements (for instance, ZA series contain toxic Al elements up to 40 wt.%), which subsequently bring up biosafety concerns. In the present work, novel Zn-1X binary alloys, with the addition of nutrition elements Mg, Ca and Sr were designed (cast, rolled and extruded Zn-1Mg, Zn-1Ca and Zn-1Sr). Their microstructure and mechanical property, degradation and in vitro and in vivo biocompatibility were studied systematically. The results demonstrated that the Zn-1X (Mg, Ca and Sr) alloys have profoundly modified the mechanical properties and biocompatibility of pure Zn. Zn-1X (Mg, Ca and Sr) alloys showed great potential for use in a new generation of biodegradable implants, opening up a new avenue in the area of biodegradable metals.

SUBMITTER: Li HF

PROVIDER: S-EPMC4448657 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Development of biodegradable Zn-1X binary alloys with nutrient alloying elements Mg, Ca and Sr.

Li H F HF Xie X H XH Zheng Y F YF Cong Y Y Zhou F Y FY Qiu K J KJ Wang X X Chen S H SH Huang L L Tian L L Qin L L

Scientific reports 20150529

Biodegradable metals have attracted considerable attentions in recent years. Besides the early launched biodegradable Mg and Fe metals, Zn, an essential element with osteogenic potential of human body, is regarded and studied as a new kind of potential biodegradable metal quite recently. Unfortunately, pure Zn is soft, brittle and has low mechanical strength in the practice, which needs further improvement in order to meet the clinical requirements. On the other hand, the widely used industrial ...[more]

PMID: 26023878

Similar Datasets

Project description:Biomedical implants and devices for tissue engineering in clinics, mainly made of polymers and stiff metallic materials, require possibly secondary surgery or life-long medicine. Biodegradable metals for biomedical implants and devices exhibit huge potential to improve the prognosis of patients. In this work, we developed a new type of biodegradable binary zinc (Zn) alloys with 16 rare earth elements (REEs) including Sc, Y, La to Nd, and Sm to Lu, respectively. The effects of REEs on the alloy microstructure, mechanical properties, corrosion behavior and in vitro and in vivo biocompatibility of Zn were systematically investigated using pure Zn as control. All Zn-RE alloys generally exhibited improved mechanical properties, and biocompatibilities compared to pure Zn, especially the tensile strength and ductility of Zn-RE alloys were dramatically enhanced. Among the Zn-RE alloys, different REEs presented enhancement effects at varied extent. Y, Ho and Lu were the three elements displaying greatest improvements in majority of alloys properties, while Eu, Gd and Dy exhibited least improvement. Furthermore, the Zn-RE alloys were comparable with other Zn alloys and also exhibited superior properties to Mg-RE alloys. The in vivo experiment using Zn–La, Zn–Ce, and Zn–Nd alloys as tibia bone implants in rabbit demonstrated the excellent tissue biocompatibility and much more obvious osseointegration than the pure Zn control group. This work presented the significant potential of the developed Zn-RE binary alloys as novel degradable metal for biomedical implants and devices. Graphical abstract (a) Material preparation and characterizations. (b) Mechanical Properties and (c) Bone-implant interfaces.Image 1 Highlights • Novel binary Zn alloys with 16 rare earth elements including Sc, Y, La–Nd, Sm–Lu were firstly developed.• The alloying of rare earth element increased the tensile strength and elongation rate of pure Zn.• The Y, Ho, and Lu were the three elements that signficantly improved most of properties of Zn.• The binary Zn-RE alloys display superior property enhancement from rare earth element compared to Mg-RE alloys.• The in vivo implantation of the Zn–La, Zn–Ce, and Zn–Nd alloys exhibited much more obvious osseointegration than the pure Zn.

Dataset Information

Development of biodegradable Zn-1X binary alloys with nutrient alloying elements Mg, Ca and Sr.

Publications

Development of biodegradable Zn-1X binary alloys with nutrient alloying elements Mg, Ca and Sr.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets