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Triethysilyl Enol Ethers in the Synthesis of Carbapenem Precursors.

ABSTRACT: A diastereoselective process for the formation of intermediates suitable for the preparation of C1 substituted carbapenems was developed. The process is readily scalable and does not involve organometallics or strong bases such as LDA.

SUBMITTER: Nguyen TQ

PROVIDER: S-EPMC4448756 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Triethysilyl Enol Ethers in the Synthesis of Carbapenem Precursors.

Nguyen Thu Q TQ Chai Weirui W Gu Jane J Cook Katie K Kim Eugene E Goetz Sam S Farni Zach Z Chepuru Monica M Cox Melina M Nguyen Pauline P Raja Hashim H Magistrado Patrick P Michael Faith F Oelschlaeger Peter P Buynak John D JD

Tetrahedron letters 20150601 23

A diastereoselective process for the formation of intermediates suitable for the preparation of C1 substituted carbapenems was developed. The process is readily scalable and does not involve organometallics or strong bases such as LDA. ...[more]

PMID: 26034332

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