Ontology highlight
ABSTRACT:
SUBMITTER: Boudreault PL
PROVIDER: S-EPMC4449265 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Boudreault Pierre-Luc PL Mattler Jennifer K JK Wender Paul A PA
Tetrahedron letters 20150601 23
Daphnanes and tiglianes are diterpenes with a shared tricyclic 5-7-6 ring system. Many members exhibit significant biological activities often associated with protein kinase C signaling. Many of these natural products (~100) have a C6-C7 α-epoxide whose influence on biological activity is little studied. Using the more readily available phorbol ester PDBu as a test substrate, we report an efficient, and potentially general, α-epoxidation method based on a vanadium-catalyzed asymmetric epoxidatio ...[more]