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Improved method for synthesis of cysteine modified hyaluronic acid for in situ hydrogel formation.

ABSTRACT: We developed a new strategy for the functionalization of hyaluronic acid by chemical modification of its C-6 hydroxyl groups through an ether bond to obtain a cysteine-hyaluronic acid conjugate. This conjugate is suitable to prepare injectable and in situ formed hydrogels cross-linked by native chemical ligation and Michael addition under mild conditions.

SUBMITTER: Zhang X 

PROVIDER: S-EPMC4449282 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Improved method for synthesis of cysteine modified hyaluronic acid for in situ hydrogel formation.

Zhang Xin X   Sun Pengcheng P   Huangshan Lingzi L   Hu Bi-Huang BH   Messersmith Phillip B PB  

Chemical communications (Cambridge, England) 20150601 47

We developed a new strategy for the functionalization of hyaluronic acid by chemical modification of its C-6 hydroxyl groups through an ether bond to obtain a cysteine-hyaluronic acid conjugate. This conjugate is suitable to prepare injectable and in situ formed hydrogels cross-linked by native chemical ligation and Michael addition under mild conditions. ...[more]

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