Ontology highlight
ABSTRACT:
SUBMITTER: Gutierrez-Achury J
PROVIDER: S-EPMC4449296 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Gutierrez-Achury Javier J Zhernakova Alexandra A Pulit Sara L SL Trynka Gosia G Hunt Karen A KA Romanos Jihane J Raychaudhuri Soumya S van Heel David A DA Wijmenga Cisca C de Bakker Paul I W PI
Nature genetics 20150420 6
Although dietary gluten is the trigger for celiac disease, risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine mapped the MHC association signal to identify additional risk factors independent of the HLA-DQA1 and HLA-DQB1 alleles and observed five new associations that account for 18% of the genetic risk. Taking these new loci together with the 57 known non-MHC loci, genetic variation can now explain up to 48% of celiac disease heritabil ...[more]