Ontology highlight
ABSTRACT:
SUBMITTER: Xu C
PROVIDER: S-EPMC4449445 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Xu Chengshan C Zhang Ling L Li Hengheng H Liu Zhihua Z Duan Lianning L Lu Chengrong C
American journal of cancer research 20150215 3
MicroRNAs play key roles in cell growth, differentiation, and apoptosis. In this study, we described the regulation and function of miR-1469 in apoptosis of lung cancer cells (A549 and NCI-H1650). Expression analysis verified that miR-1469 expression significantly increased in apoptotic cells. Overexpression of miR-1469 in lung cancer cells increased cell apoptosis induced by etoposide. Additionally, we identified that Stat5a is a downstream target of miR-1469, which can bind directly to the 3'- ...[more]