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Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models.


ABSTRACT: This research was carried out to investigate the thrombolytic effects of the methanolic extracts of five Bangladeshi plants. Phytochemical metabolites of those plants have been identified to elucidate whether the plant-derived metabolites are linked with the thrombolytic effects. Potential computer aided models were adopted in this study to find out a structure-function correlation between the phytochemical constituents and thrombolytic effects using the secondary metabolites as ligands and tissue plasminogen activator (t-PA) as receptor for the best fit ligand-receptor interaction.

SUBMITTER: Mahmud S 

PROVIDER: S-EPMC4449917 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models.

Mahmud Sakib S   Akhter Samina S   Rahman Md Atiar MA   Aklima Jannatul J   Akhter Shaheen S   Merry Syeeda Rayhana SR   Jubair S M Rakibul SM   Dash Raju R   Emran Talha Bin TB  

Evidence-based complementary and alternative medicine : eCAM 20150517


This research was carried out to investigate the thrombolytic effects of the methanolic extracts of five Bangladeshi plants. Phytochemical metabolites of those plants have been identified to elucidate whether the plant-derived metabolites are linked with the thrombolytic effects. Potential computer aided models were adopted in this study to find out a structure-function correlation between the phytochemical constituents and thrombolytic effects using the secondary metabolites as ligands and tiss  ...[more]

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