Ontology highlight
ABSTRACT:
SUBMITTER: Cueva JP
PROVIDER: S-EPMC4450370 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20150506 10
Buprenorphine is a successful analgesic and treatment for opioid abuse, with both activities relying on its partial agonist activity at mu opioid receptors. However, there is substantial interest in its activities at the kappa opioid and nociceptin/orphanin FQ peptide receptors. This has led to an interest in developing compounds with a buprenorphine-like pharmacological profile but with lower efficacy at mu opioid receptors. The present article describes aryl ring analogues of buprenorphine in ...[more]