Ontology highlight
ABSTRACT:
SUBMITTER: Shroff EH
PROVIDER: S-EPMC4450371 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Shroff Emelyn H EH Eberlin Livia S LS Dang Vanessa M VM Gouw Arvin M AM Gabay Meital M Adam Stacey J SJ Bellovin David I DI Tran Phuoc T PT Philbrick William M WM Garcia-Ocana Adolfo A Casey Stephanie C SC Li Yulin Y Dang Chi V CV Zare Richard N RN Felsher Dean W DW
Proceedings of the National Academy of Sciences of the United States of America 20150511 21
The MYC oncogene is frequently mutated and overexpressed in human renal cell carcinoma (RCC). However, there have been no studies on the causative role of MYC or any other oncogene in the initiation or maintenance of kidney tumorigenesis. Here, we show through a conditional transgenic mouse model that the MYC oncogene, but not the RAS oncogene, initiates and maintains RCC. Desorption electrospray ionization-mass-spectrometric imaging was used to obtain chemical maps of metabolites and lipids in ...[more]