Ontology highlight
ABSTRACT:
SUBMITTER: van der Graaf A
PROVIDER: S-EPMC4450394 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
van der Graaf Adriaan A Wardenaar René R Neumann Drexel A DA Taudt Aaron A Shaw Ruth G RG Jansen Ritsert C RC Schmitz Robert J RJ Colomé-Tatché Maria M Johannes Frank F
Proceedings of the National Academy of Sciences of the United States of America 20150511 21
Stochastic changes in cytosine methylation are a source of heritable epigenetic and phenotypic diversity in plants. Using the model plant Arabidopsis thaliana, we derive robust estimates of the rate at which methylation is spontaneously gained (forward epimutation) or lost (backward epimutation) at individual cytosines and construct a comprehensive picture of the epimutation landscape in this species. We demonstrate that the dynamic interplay between forward and backward epimutations is modulate ...[more]