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The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes.

ABSTRACT: The novel avian origin influenza A (H7N9) virus has caused severe diseases in humans in eastern China since the spring of 2013. Fatal outcomes of H7N9 infections are often attributed to the severe pneumonia and acute respiratory distress syndrome (ARDS). There is urgent need to discover biomarkers predicting the progression of disease and fatal outcome of potentially lethal flu infections, based on sound statistical analysis. We discovered that 34 of the 48 cytokines and chemokines examined in this study were significantly elevated in the plasma samples from patients infected with H7N9. We report for the first time that the levels of MIF, SCF, MCP-1, HGF, and SCGF-? are highly positively linked to disease severity and the profile of mediators MIF, SCF, MCP-1, HGF, SCGF-?, IP-10, IL-18, and IFN-? is an independent outcome predictor.

SUBMITTER: Guo J 

PROVIDER: S-EPMC4450576 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes.

Guo Jing J   Huang Fengming F   Liu Jun J   Chen Yu Y   Wang Wei W   Cao Bin B   Zou Zhen Z   Liu Song S   Pan Jingcao J   Bao Changjun C   Zeng Mei M   Xiao Haixia H   Gao Hainv H   Yang Shigui S   Zhao Yan Y   Liu Qiang Q   Zhou Huandi H   Zhu Jingdong J   Liu Xiaoli X   Liang Weifeng W   Yang Yida Y   Zheng Shufa S   Yang Jiezuan J   Diao Hongyan H   Su Kunkai K   Shao Li L   Cao Hongcui H   Wu Ying Y   Zhao Min M   Tan Shuguang S   Li Hui H   Xu Xiaoqing X   Wang Chunmei C   Zhang Jianmin J   Wang Li L   Wang Jianwei J   Xu Jun J   Li Dangsheng D   Zhong Nanshan N   Cao Xuetao X   Gao George F GF   Li Lanjuan L   Jiang Chengyu C  

Scientific reports 20150601

The novel avian origin influenza A (H7N9) virus has caused severe diseases in humans in eastern China since the spring of 2013. Fatal outcomes of H7N9 infections are often attributed to the severe pneumonia and acute respiratory distress syndrome (ARDS). There is urgent need to discover biomarkers predicting the progression of disease and fatal outcome of potentially lethal flu infections, based on sound statistical analysis. We discovered that 34 of the 48 cytokines and chemokines examined in t  ...[more]

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