Ontology highlight
ABSTRACT:
SUBMITTER: Mehlotra RK
PROVIDER: S-EPMC4450653 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Mehlotra Rajeev K RK Ziats Mark N MN Bockarie Moses J MJ Zimmerman Peter A PA
European journal of clinical pharmacology 20060228 4
<h4>Objective</h4>Cytochrome P450 2B6 (CYP2B6) is involved in the metabolism of artemisinin drugs, a novel series of antimalarials. Our aim was to analyze the prevalence of the most commonly observed CYP2B6 alleles in malaria-endemic populations of West Africa (WA) and Papua New Guinea (PNG).<h4>Methods</h4>Using a post-PCR ligation detection reaction-fluorescent microsphere assay, frequencies of CYP2B6*1A, *2, *3, *4, *5, *6, *7, and *9 were determined in WA (n=166) and PNG (n=174). To compare ...[more]