Ontology highlight
ABSTRACT:
SUBMITTER: Panaccione R
PROVIDER: S-EPMC4450894 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Panaccione Remo R Sandborn William J WJ Gordon Glenn L GL Lee Scott D SD Safdi Alan A Sedghi Shahriar S Feagan Brian G BG Hanauer Stephen S Reinisch Walter W Valentine John F JF Huang Bidan B Carcereri Roberto R
Inflammatory bowel diseases 20150601 6
<h4>Background</h4>This study assessed the efficacy and safety of briakinumab, a human anti-IL-12/23p40 monoclonal antibody, compared with placebo for the induction and maintenance of remission in patients with moderately to severely active Crohn's disease.<h4>Methods</h4>In this phase 2b, multicenter, double-blind, parallel group study, 246 patients stratified by prior tumor necrosis factor-antagonist use and response, were randomized (1:1:1:3) to 4 intravenous induction regimens: placebo, 200, ...[more]