Using Genome-scale Models to Predict Biological Capabilities.
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ABSTRACT:
SUBMITTER: O'Brien EJ
PROVIDER: S-EPMC4451052 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
Using Genome-scale Models to Predict Biological Capabilities.
O'Brien Edward J EJ Monk Jonathan M JM Palsson Bernhard O BO
Cell 20150501 5
Constraint-based reconstruction and analysis (COBRA) methods at the genome scale have been under development since the first whole-genome sequences appeared in the mid-1990s. A few years ago, this approach began to demonstrate the ability to predict a range of cellular functions, including cellular growth capabilities on various substrates and the effect of gene knockouts at the genome scale. Thus, much interest has developed in understanding and applying these methods to areas such as metabolic ...[more]
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