Genomic profiling guides the choice of molecular targeted therapy of pancreatic cancer.
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ABSTRACT:
SUBMITTER: Frank TS
PROVIDER: S-EPMC4451193 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
Genomic profiling guides the choice of molecular targeted therapy of pancreatic cancer.
Frank Thomas S TS Sun Xiaotian X Zhang Yuqing Y Yang Jingxuan J Fisher William E WE Gingras Marie-Claude MC Li Min M
Cancer letters 20150415 1
Pancreatic cancer has the worst five-year survival rate of all malignancies due to its aggressive progression and resistance to therapy. Current therapies are limited to gemcitabine-based chemotherapeutics, surgery, and radiation. The current trend toward "personalized genomic medicine" has the potential to improve the treatment options for pancreatic cancer. Gene identification and genetic alterations like single nucleotide polymorphisms and mutations will allow physicians to predict the effica ...[more]
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