Molecular mechanisms for alcoholic hepatitis based on analysis of gene expression profile.

ABSTRACT: BACKGROUND:Alcoholic hepatitis (AH) is an acute manifestation of alcoholic liver disease with high mortality rates. OBJECTIVES:Our aim was to study the molecular mechanisms of AH. MATERIALS AND METHODS:The differentially expressed genes (DEGs) in liver between AH and control cases were identified by analyzing the GSE28619 microarray data using t-test. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and Gene Ontology (GO) enrichment analyses were performed using DAVID online tool. The protein-protein interaction (PPI) network was constructed using Search Tool for the Retrieval of Interacting Genes (STRING) and the subnetwork was identified by BioNet. Both PPI network and subnetwork were visualized using the Cytoscape software. RESULTS:Total 908 DEGs (551 up- and 357 down-regulat

SUBMITTER: Liu M 

PROVIDER: S-EPMC4451276 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature