Ontology highlight
ABSTRACT:
SUBMITTER: Laucho-Contreras ME
PROVIDER: S-EPMC4451404 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Laucho-Contreras Maria E ME Polverino Francesca F Gupta Kushagra K Taylor Katherine L KL Kelly Emer E Pinto-Plata Victor V Divo Miguel M Ashfaq Naveed N Petersen Hans H Stripp Barry B Pilon Aprile L AL Tesfaigzi Yohannes Y Celli Bartolome R BR Owen Caroline A CA
The European respiratory journal 20150219 6
Club cell secretory protein-16 (CC16) is the major secreted product of airway club cells, but its role in the pathogenesis of chronic obstructive pulmonary disease (COPD) is unclear. We measured CC16 airway expression in humans with and without COPD and CC16 function in a cigarette smoke (CS)-induced COPD murine model. Airway CC16 expression was measured in COPD patients, smokers without COPD and non-smokers. We exposed wildtype (WT) and CC16(-/-)mice to CS or air for up to 6 months, and measure ...[more]