Ontology highlight
ABSTRACT:
SUBMITTER: Kuo HC
PROVIDER: S-EPMC4451985 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Kuo Ho-Chang HC Hsu Yu-Wen YW Wu Mei-Shin MS Woon Peng Yeong PY Wong Henry Sung-Ching HS Tsai Li-Jen LJ Lin Ruo-Kai RK Klahan Sukhontip S Hsieh Kai-Sheng KS Chang Wei-Chiao WC
Mediators of inflammation 20150518
Kawasaki disease (KD) is characterized by pediatric systemic vasculitis of an unknown cause. The low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) gene was reported to be involved in the susceptibility of KD. DNA methylation is one of the epigenetic mechanisms that control gene expression; thus, we hypothesized that methylation status of CpG islands in FCGR2A promoter associates with the susceptibility and therapeutic outcomes of Kawasaki disease. In this study, 36 KD patients a ...[more]