A Novel Transgenic Mouse Line for Tracing MicroRNA-155-5p Activity In Vivo.
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ABSTRACT:
SUBMITTER: Phiwpan K
PROVIDER: S-EPMC4452368 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
A Novel Transgenic Mouse Line for Tracing MicroRNA-155-5p Activity In Vivo.
Phiwpan Krung K Guo Jie J Zhang Wei W Hu Tanyu T Boruah Bhargavi M BM Zhang Jianhua J Zhou Xuyu X
PloS one 20150601 6
MicroRNA-155 (miR-155) plays significant role in various physiological processes involving both innate and adaptive immunity. miR-155 expression level changes dynamically during various immune responses. However, current approaches for miR-155 detection at the RNA level do not precisely reflect the real-time activity. Herein, we generated a transgenic mouse line (R26-DTR-155T) for determination of miR-155-5p activity in vivo by inserting miR-155-5p target sequence downstream of a reporter transg ...[more]
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