A Glycosylation Mutant of Trypanosoma brucei Links Social Motility Defects In Vitro to Impaired Colonization of Tsetse Flies In Vivo.
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ABSTRACT:
SUBMITTER: Imhof S
PROVIDER: S-EPMC4452570 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
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A Glycosylation Mutant of Trypanosoma brucei Links Social Motility Defects In Vitro to Impaired Colonization of Tsetse Flies In Vivo.
Imhof Simon S Vu Xuan Lan XL Bütikofer Peter P Roditi Isabel I
Eukaryotic cell 20150410 6
Transmission of African trypanosomes by tsetse flies requires that the parasites migrate out of the midgut lumen and colonize the ectoperitrophic space. Early procyclic culture forms correspond to trypanosomes in the lumen; on agarose plates they exhibit social motility, migrating en masse as radial projections from an inoculation site. We show that an Rft1(-/-) mutant needs to reach a greater threshold number before migration begins, and that it forms fewer projections than its wild-type parent ...[more]
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