Ontology highlight
ABSTRACT:
SUBMITTER: Liu D
PROVIDER: S-EPMC4452692 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Liu Deli D Xiong Huan H Ellis Angela E AE Northrup Nicole C NC Dobbin Kevin K KK Shin Dong M DM Zhao Shaying S
PLoS genetics 20150601 6
Spontaneous canine head and neck squamous cell carcinoma (HNSCC) represents an excellent model of human HNSCC but is greatly understudied. To better understand and utilize this valuable resource, we performed a pilot study that represents its first genome-wide characterization by investigating 12 canine HNSCC cases, of which 9 are oral, via high density array comparative genomic hybridization and RNA-seq. The analyses reveal that these canine cancers recapitulate many molecular features of human ...[more]